Почему вариат с and может не работать? в документации сказано:

The sqlite3_open_v2() interface works like sqlite3_open() except that it accepts two additional parameters for additional control over the new database connection. The flags parameter to sqlite3_open_v2() can take one of the following three values, optionally combined with the SQLITE_OPEN_NOMUTEX, SQLITE_OPEN_FULLMUTEX, SQLITE_OPEN_SHAREDCACHE, SQLITE_OPEN_PRIVATECACHE, and/or SQLITE_OPEN_URI flags:

QLITE_OPEN_READWRITE
SQLITE_OPEN_READONLY